The insulin sensitiser metformin regulates chicken Sertoli and germ cell populations
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چکیده
منابع مشابه
Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis.
Spermatogenesis is the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the epithelial cycle were first described, reproductive biologists have been in pursuit of one question: How can a spermatogonium traverse the epithelium, while at the same time differentiating into elongate spermatids that remai...
متن کاملControl of Sertoli and germ cell populations in the cock and sheep testes.
Sertoli cells are involved in the control of spermatogenesis. In adult animals, the Sertoli cell stocks, fixed before puberty, are highly correlated with those of the germ cells. Some factors influencing Sertoli cell stock formation have been analyzed: 1) Early hemicastration of impuberal animals showed that the proliferative activities of the Sertoli and the germ cells before puberty, rather t...
متن کاملExtracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro
Sertoli cell preparations isolated from 10-day-old rats were cultured on three different substrates: plastic, a matrix deposited by co-culture of Sertoli and peritubular myoid cells, and a reconstituted basement membrane gel from the EHS tumor. When grown on plastic, Sertoli cells formed a squamous monolayer that did not retain contaminating germ cells. Grown on the matrix deposited by Sertoli-...
متن کاملAB199. Human germ cell secreting factor Nodal regulates Sertoli cell functions
Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. mechanisms of spermatogenesis. Nodal could promote proliferation of mouse spermatogonial stem/progenitor cells via Smad2/3 and oct-4 activation. The objective of this study was to determine the role of Nodal signaling in the differentiation of iPS cells to male germ ce...
متن کاملRegulation of Sertoli cell and germ cell differentation.
Unwanted childlessness affects approximately one in six couples worldwide. According to the World Health Organization, in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. The incidence of male factor infertility in the general population is approximately 7%. The majority of these men experience irreversible ...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2016
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-15-0565